Dosage and Administration: The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Dexamethasone commonly is used in horses to treat allergic reactions such as respiratory allergies, chronic obstructive pulmonary disease (heaves), hives, itching and inflammatory diseases including arthritis. 7. How Organized Are Your Horses Health Records? A native of Japan, Dr. Hensel subsequently moved to Basel, Switzerland, where she opened a veterinary dermatology practice in 2014. Anecdotal reports indicate that oclacitinib is not very effective in managing recurrent and/or chronic otitis and interdigital furunculosis associated with allergies, and a sudden loss of efficacy is often associated with bacterial or. Insect and pollen season is here. Successful treatment of atopic dermatitis with the JAK1 inhibitor oclacitinib. See how Apoquel works differently from steroids and cyclosporines, Discover how Apoquel can relieve allergic itch through an 8-week food trial, Hear from your peers about why Apoquel is their first choice for allergic itch relief, Explore the United States of Apoquel to see how Apoquel has benefited veterinarians in your region, Hear real stories of allergic itch relief from pet owners, See how Zoetis Petcare Rewards can benefit your practice, Informational resources for you to download and utilize within your practice, Provide additional information about Apoquel to pet owners with these resources, Continue therapy once daily (SID) thereafter for maintenance. Treatment success in three Andean bears (Tremarctos ornatus) with alopecia syndrome using Oclacitinib maleate (Apoquel). Haugh IM, Watson IT, Menter MA. Unlike steroids, the drug has minimal impact on the immune system. Cosgrove SB, Wren JA, Cleaver DM, et al. We can let your veterinarian know that you are interested in our compounded Dexamethasone. Not really cheap any way you shake it, but considering that she was on zyretc, dex, smarthbreathe ultra, respi-free previously. 3. 27. Milder cases of asthma are still associated with coughing, airway inflammation, mucous production, and poor performance.. Pet owners should visit ZoetisPetcare.com for product info, rewards and support. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Oclacitinib is available in 3 different tablet sizes: 3.6, 5.4, and 16 mg. Left untreated, these conditions can not only cause discomfort but also lead to raw, broken skin that allows bacteria to invade and infect. Gonzales AJ, Humphrey WR, Messamore JE, et al. Your Price: $2.20. Pollen and other plant-based aeroallergens are the source of their distress, and they fare much better inside a well-ventilated barn. I actually have 2 horses now on serum and one I eliminated the food specific allergens from his diet. This is a new treatment option, and currently the tablets are not FDA approved for horses, only dogs. Frank RK, Galvan BA, Schoell AR, et al. After completing a doctorate thesis and a rotating internship at the University of Zurich, Switzerland, he moved to the United States, where he completed a 3-year veterinary dermatology residency at the University of Georgia in 2004. 13. They result in the production of antibodies that block the allergy-causing IgE from recognizing the allergen, thus preventing the associated symptoms.. 1800PetMeds is your online pet store offering discount prices on pet supplies, medications, vitamins and supplements for your pet. So lets review why allergies happen, how they affect your horses body, and how to treat themor, better yet, how to avoid them altogether. If the diagnosis is wrong or the medication affects the horse adversely, you could endanger your horse's life. 22. Vet Dermatol Natural Disaster: Are You and Your Horse Ready for Emergency Evacuation? At that point, the treatment can be changed to oclacitinib. Cost for the initial course of treatment (about 12 days) will be around $300-400. Transdermal applicator that gives easy & accurate dosing every time. Cats have been reported to drink more water while receiving this drug and also experience be- havior changes while receiving hydroxyzine. Rosenkrantz WS, Bourgeois AS. Fultz adds that over time this process teaches the immune system to tolerate exposure to substances it previously considered irritating. In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days. Im hoping those are things I can stop giving, so that will help some with overall cost. This would be treatment with a systemic steroid (usually dexamethasone or prednisolone). The downside is that it can cause laminitis and can suppress their immune system. Many allergic reactions are evident as a mild case of transient hives. Though rare, allergic reactions to medications and vaccines also occur. The steroids are usually given orally, but we may want to start with injections for a week or so in severely affected horses. However, the study showed that cyclosporine caused a 3-fold higher risk for developing gastrointestinal side effects (vomiting and diarrhea) compared with oclacitinib.12, Despite its delayed effects, cyclosporine is still a popular drug to treat canine atopic dermatitis because in some cases it can be dosed every other day or even every third day after initial daily treatment. (https://www.zoetispetcare.com) I get $9 back for every 30 pills I order, it goes onto a Mastercard debit card that can only be used at a vets office but I spend plenty of money there. Veterinarians are especially wary of administering corticosteroids to allergic horses that suffer from pituitary pars intermedia dysfunction, insulin dysregulation, and/or equine metabolic syndrome, because these conditions are also risk factors for laminitis. This treatment is typically effective, but the steroid is still absorbed into the body, which can result in laminitis risk, similar to Option 1. In many cases, symptomatic therapy alone with drugs such as oclacitinib is insufficient to control allergies long-term. Apoquel Overdose Information Dogs that received overdoses in safety studies had side effects that included one or more of the following: vomiting, diarrhea, cysts between the toes, skin inflammation, papilloma's (warts), pneumonia, enlarged lymph nodes, and decreased blood cell production. 6. She still has her mane this year- which is good! Apoquel Dosage for Dogs. Table of Contents hide Apoquel dosage for dogs chart Apoquel for Dogs Reviews: Does It Really Work? The dosage will depends on your dog's weight. Currently, White is part of a team evaluating the possibility of delivering allergy shots in the form of a juice squirted under the horses tongue. These inhaled substances can trigger an allergic response that causes narrowing of the airways, mucous secretion, and cough., Luckily, minimizing common allergens in your horses environment could suffice to restore his comfort and breathing. This site is for US animal healthcare professionals. These and other kinase-inhibiting drugs sometimes work very well to stop the itching. While easy to perform, Fultz says its not always accurate at predicting the exact allergens. 8. While easy to perform, Fultz says its not always accurate at predicting the exact allergens. Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including environmental allergies, food allergies, flea allergy, and contact allergies. It is initially prescribed twice daily for 14 days, then once daily for maintenance therapy. Allergies are generally managed based on the severity of clinical signs. I was one of the veterinarians involved in early field trials for Apoquel in horses. This makes it a common site for the bodys expression of allergic reactions. 11. Allergies can develop at any time, in any horse, and for virtually any reason. Copyright 2023 Today's Veterinary Practice Web DesignbyPHOS Creative. The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study. I hear the result have been spectacular. The concentration of the drug is 500 mg/ml. Depending on the size of a cat and the condition being treated, a veterinarian may elect to alter the dosage. Dexamethasone is a synthetic corticosteroid hormone used to manage inflammation in diseases or conditions in which the immune system has a significant role. 23. The recommended Apoquel (main ingredient, oclacitinib) dosage for dog use is as follows: The recommended dosage is 0.18 to 0.27 mg of oclacitinib per pound of body weight, for the first 14 days. Cyclosporine, which is approved for the treatment of canine atopic dermatitis, has an onset of efficacy of up to 4 weeks. Allergies primarily affect the immune, respiratory, and integumentary (skin) systems and, if unmanaged, can seriously impact an animals performance and well-being. Loft K, Simon B. In the past 5 years, however, oclacitinib (Apoquel; ), a Janus kinase (JAK) inhibitor, has become another important drug in the management of allergic pruritus. Old fashioned drugs like Benadryl and steroids don't work well any more. IgE binds to cells in the body and releases inflammatory molecules. Equine Asthma- yep, that's the new name for "heaves," "RAO," "COPD" or whatever else we've called it over the years! 9. Therefore, the recommended initial dosage for dogs 6.6-9.9 lbs is of a 3.6 mg tablet twice daily. According to the manufacturer's dosage chart, a large breed weighing between 130 and 175lbs should take two Apoquel 16mg daily. Apoquel is typically administered in tablet form at 0.4-0.6mg per kilo of body weight, or 0.18-0.27mg per pound of body weight, every 12 hours or twice a day. On the topic of simple and economical allergy management, a readily accessible ingredient that helps many horses is, Recently, we have found that latex, which is everywhere in the horses environmentembedded in riding surfaces and racetracks, for examplemay be associated with severe equine asthma, he says. Dosage and treatment schedule The recommended initial dose is 0.4 to 0.6 mg oclacitinib/kg bodyweight, administered orally, twice daily for up to 14 days. Some allergic reactions are unexpected, as White has realized through his research. Vet Dermatol 2018:29:371 (abstract). For dogs weighing between 10 and 14.9 pounds, give of a 5.4 mg tablet twice daily as dosage. 14. Apoquel can be administered with or without food. Bursatti, Leeches) in Dogs, Cats and Horses. Vercelli A, Cornegliani L. Use of oclacitinib in treatment of canine idiopathic ear tip vasculitis. Most commonly, horses develop an allergy to the saliva of biting insects (e.g., gnats, black flies, stable flies, horn flies) known as insect bite hypersensitivity (IBH). The pharmacokinetics of oclacitinib maleate, a Janus kinase inhibitor, in the dog. Also. She then completed a 1-year rotating small animal internship in Massachusetts followed by a 3-year veterinary dermatology residency in Georgia. Vet Dermatol 2015;26:134 (abstract). We cannot be sure of accurate dosing when tablets are quartered, and thus this practice is not recommended. Acepromazine affects animals and humans by depressing the central nervous system. It generally reduces itching very quickly within 24 hours and is felt to be as effective as corticosteroids. She is a New-York-based freelance author with a passion for equine health and veterinary care. Specifically, studies in cats have used the following dosage: Initially, doses ranging from 0.4 to 1.2 mg/kg body weight, twice daily, for 24-28 days. Why Do Some Horses Develop Respiratory EHV-1 and Others EHM? Dr. Patrick Hensel is a 1996 graduate of the University of Bern, Switzerland. Adverse events were reported in less than 5% of dogs, including urinary tract infection, vomiting, otitis, pyoderma, and diarrhea.9 A subsequent study concluded that there is no increased risk for urinary tract infections.10, The efficacy of oclacitinib was also compared to that of other drugs such as prednisolone and cyclosporine. 405 HERON DRIVE SUITE 200 SWEDESBORO, NJ 08085-1749 | 2004-2023 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED. Do not use in breeding, pregnant, or lactating dogs. This site is intended for US animal healthcare professionals. Avoiding Allergies Avoid storing hay in the same barn as sensitive horses. Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. RELATED CONTENT | Infographic: Equine Allergies. On the label for dogs, Apoquel is used every 12 hours for the first 14 days of use, then backed down to dosing every 24 hours once a day. The most common side effects associated with Apoquel are vomiting, diarrhea, and lethargy. The onset of efficacy for oclacitinib is up to 1 week, but Little et al found that after 4 weeks of treatment, both drugs demonstrated comparable control of clinical signs. Find out more. ACVIM, a Florida-based large animal internal medicine specialist with an interest in respiratory disease. Helpful steps you can take include providing full-body fly apparel, applying fly spray liberally, avoiding turnout at dusk and dawn, and using fans in stalls to disrupt insect flying patterns. However, these studies have shown that oclacitinib can be a good alternative therapy to treat feline pruritus, especially for patients that do not respond to other treatments or do not tolerate steroids. Treatment success in three Andean bears (Tremarctos ornatus) with alopecia syndrome using Oclacitinib maleate (Apoquel). Option 2 is the Aservo Equihaler. 16. Drake GJ, Nuttall T, Lpez J, et al. The dosage for dogs 10-14.9 lbs is of a 5.4 mg tablet twice daily. On the topic of simple and economical allergy management, a readily accessible ingredient that helps many horses is flaxseed. Until recently, glucocorticoids (systemic and/or topical) and cyclosporine have been considered the most effective symptomatic treatment options to manage atopic dermatitis.5 Oclacitinib is now also an effective option (BOX 1). You are encouraged to speak with your prescriber as to the appropriate use of any medication. Rectal Prolapse in Dogs and Cats. Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction.11 Little et al compared oclacitinib to cyclosporine. One of the things the trials found on using apoquel with horses is that they need a relatively small dose. This content is intended for counseling purposes only. Oclacitinib in feline nonflea-, nonfood-induced hypersensitivity dermatitis: results of a small prospective pilot study of client-owned cats. It is an anti-inflammatory drug from the class of drugs known as Janus kinase (JAK) inhibitors. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. Licorice Roo t (Glycyrrhiza glabra) This sweet and soothing herb has been used medicinally for over 3,000 years. It's touted as being "a fast-acting and safe treatment for the control of acute and chronic canine pruritus." Pruritus means itching. My mare started on 5 pills every day and then we were able to move her down to 5 pills every other day. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Works on all common sources of allergens. has been administered by veterinarians to help horses of . 19. In atopic dermatitis, it is mainly mediated by a large group of proinflammatory and proallergic Th2 cytokines (e.g., interleukin [IL]-4, IL-5, IL-10, IL-13, IL-31). Until recently, glucocorticoids (systemic and/or topical) and cyclosporine have been considered the most effective symptomatic treatment options to manage atopic dermatitis. Treatment will probably need to repeated somewhere between 1 and 6 weeks after the initial treatment course. Rosenkrantz WS, Bourgeois AS. Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Log in to fill, refill or renew the medication prescribed by your veterinarian. One of my horses was tested at New Bolton (he has since passed away) and I was told that a serum wasnt possible or effective for most of his food-bourne allergies. The Horsesexperts answer your questions during a monthly live audio event. So I want to make sure she has the support she needs to acclimate to hot humid summer weather. Thats def not nothing but its not insane. Breeding and Reproduction Horse breeding from planning through foal care; Diseases and Conditions Horse-health-problem risk factors, prevention, diagnosis, and treatment; Farm and Barn . Vet Dermatol 2015;26(3):171-179, e35. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. And I am debating spreading even further to every 2 days to see how she does, but I am a bit nervous to do so, especially when its so hot. Banovic F, Tarigo J, Gordon H, et al. Vet Dermatol 2017;28(5):485-e113. Many allergens can cause skin reactions. But you're making a deal with the devil when you use these . See full Excede for Swine Prescribing Information. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. 2. APQ-01043R3, halved to ensure that the ingredients are equally distributed. In a 2019 study Radwanski et al. 22. This study showed that pruritus was improved in only 42% of the study population; thus, use of oclacitinib in cats did not seem to be as effective as in dogs.17 A follow-up study was conducted with a higher dose (0.7 to 1.2 mg/kg) and a longer induction period (28 days). Panteri A, Strehlau G, Helbig R, et al. Topical suspension administered in the ear. Horse dosing is 5 pills. Equine Regenerative Therapies for Managing Arthritis in Horses, Infographic | 12 Smart At-Home Biosecurity Practices for Horse Owners, Infographic | How To Keep Your Horses Joints Healthy. Food allergies in particular you cant always do the serum for. The innovative formula of the drug allows you . I paid $250 for 100 pills (thats 20 5-pill doses). Because many respiratory allergies come from the dust in hay and bedding, veterinarians generally recommend maximizing fresh-air time through turnout. Maximizing ventilation when horses are stalled and bedding with low-dust options such as wood byproducts; Purchasing dust- or mold-free hay and wetting, soaking, or steaming it prior to feeding to reduce inhaled particles; and Offering an alternative feed than hay for low-dust options. The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up . The efficacy and safety of oclacitinib have been assessed in various studies. Pruritus is a common clinical sign in allergic skin diseases. Oclacitinib is available in 3 different tablet sizes: 3.6, 5.4, and 16 mg. Since oclacitinib is a rather weak anti-inflammatory drug, it was suggested that remission of active moderate to severe atopic dermatitis be induced with a course of a broad inflammation-targeting drug, such as a short-acting glucocorticoid, until clinical signs become mild. . Ortalda C, Noli C, Colombo S, et al. Saridomichelakis MN, Olivry T. An update on the treatment of canine atopic dermatitis. She reports choosing Apoquel over corticosteroids in several of her allergic patients that are also at risk for developing laminitis. Initially, the recommended dose of 0.4 to 0.6 mg/kg should be given twice daily for up to 14 days. Apoquel reduces dog itch, and also decreases inflammation, redness, or swelling of the skinso your dog feels better as quickly as possible What is Apoquel Tablet? Blood was collected prior to drug administration and at 15 min, 30 min, 45 min, 1, 2, 4, 6, 8 . Search term . This encourages the natural drainage of irritants, allergens, and bacteria from the airways.. The recommended Apoquel dosage for dogs is 0.18 to 0.27 mg per lb of body weight (0.4-0.6 mg/kg) once a day. 8. This regimen may work better because oclacitinib has a short half-life of 4 hours. Oclacitinib can be given without food and may be discontinued without tapering. Recently, one group has looked into immunomodulatory properties of oclacitinib by observing canine T-cell proliferation and cytokine productions in vitro. Allergen avoidance and allergen-specific immunotherapy are measures that address the allergy itself; various drugs are available for symptomatic management. Binding of these cytokines to their receptors activates the JAK-STAT (signal transducers and activators of transcription) pathway, which leads to further cytokine production.1 In recent studies, IL-31 has been shown to play an important role in pruritus, and elevated serum levels of IL-31 have been found in many atopic dogs.2, There are 4 JAK families in mammals: JAK1, JAK2, JAK3, and TYK2. Oclacitinib preferably inhibits JAK1 and, to a lesser degree, JAK3, resulting in decreased activity of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31).4. 3. Use code GOODRX20 Sponsored by Sometimes it goes overboard and reacts in the face of a generally harmless substancewhich the body begins to recognize as an allergenand an allergic reaction occurs. Apoquel starts relieving allergic dog itch and inflammation due to skin allergies within 4 hours and controls it within 24 hours. Available As Tablets For use with Canine Strengths 3.6 mg 5.4 mg 16 mg So I think cost becomes dependent on that. Apoquel should be administered orally, twice daily for up to 14 days, and then once daily for maintenance therapy. It definitely makes them more comfortable. 20. I spend $150 a month on my horse on apoquel. Is it possible to cure an allergy? Before your vet administers immunotherapy, though, you must identify your horses respiratory and skin allergies. J Vet Pharmacol Ther 2014;37(4):317-324. Levy BJ, Linder KE, Olivry T. The role of oclacitinib in the management of ischaemic dermatopathy in four dogs. Qualifies for Zoetis Petcare Rewards! 3 Can be used for long-term maintenance or short-term therapy in dogs 12 months of age . Merck & Co., Inc., Rahway, NJ, USA (known as MSD outside of the US and Canada) is dedicated to using the power of leading-edge science to save and improve lives around the world. I had a cat on it years ago and it was $$$$ but it was the only thing that worked for her. Download Apoquel Information Sheet. But Im not sure how much the long term cost will be yet. This product is a hand-held device that administers an anti-inflammatory mist into the horses nostril. Her asthma had gotten so bad I thought I wouldnt be able to ride her again, but now we are back to w-t-c. She is down to every other day. Really? 5. Panteri A, Strehlau G, Helbig R, et al.